Melanie Griffith (født 9. august 1957) er en amerikansk skuespiller. Hun er datter af Tippi Hedren og Peter Griffith.

Melanie Griffith har medvirket i over 50 film og tv-produktioner. En af hendes mest kendt roller er i filmen Working Girl (1988), hvor hun modtog en Golden Globe og blev nomineret til en Oscar.

Filmografi thumb|upright|right|Griffith i december 2007 År Titel Rolle Noter 1969 Smith! Extra ukrediteret 1973 The Harrad Experiment Extra ukrediteret 1975 Night Moves Delly Grastner 1975 The Drowning Pool Schuyler Devereaux 1975 Smile Karen Love 1976 Once an Eagle Jinny Massengale Tv mini-serie 1977 The Garden (Ha-Gan) Young Girl 1977 One on One The Hitchhiker 1977 Joyride Susie 1978 Daddy, I Don't Like it Like This Girl in Hotel Tv film 1978 Steel Cowboy Johnnie Tv film 1981 Roar Melanie 1981 Underground Aces Lucy 1981 The Star Maker Dawn Barnett Youngblood Tv film 1981 She's in the Army Now Pvt. Sylvie Knoll Tv film 1981 Golden Gate Karen Tv film 1984 Body Double Holly Body National Society of Film Critics Award for Best Supporting ActressNomineret — Golden Globe Award for Best Supporting Actress – Motion PictureNomineret — New York Film Critics Circle Award for Best Supporting Actress (2 plads) 1985 Fear City Loretta 1985 Alfred Hitchcock Presents Girl Tv serie (1 episode) 1986 Something Wild Audrey Hankel aka Lulu Nomineret — Golden Globe Award for Best Actress – Motion Picture Musical or Comedy 1987 Cherry 2000 Edith 'E' Johnson Lige til video 1988 The Milagro Beanfield War Flossie Devine 1988 Stormy Monday Kate 1988 Working Girl Tess McGill Boston Society of Film Critics Award for Best ActressGolden Globe Award for Best Actress – Motion Picture Musical or ComedyNomineret — Academy Award for Best ActressNomineret — BAFTA Award for Best Actress in a Leading RoleNomineret — National Society of Film Critics Award for Best Actress (3 plads) 1990 Women and Men: Stories of Seduction Lureen Tv film 1990 In the Spirit Hadley 1990 Pacific Heights Patty Palmer 1990 The Bonfire of the Vanities Maria Ruskin Nomineret — Golden Raspberry Award for Worst Actress 1991 Paradise Lily Reed 1992 Shining Through Linda Voss Golden Raspberry Award for Worst Actress 1992 A Stranger Among Us Emily Eden 1993 Born Yesterday Billie Dawn 1994 Milk Money V 1994 Nobody's Fool Toby Roebuck 1995 Buffalo Girls Dora DuFran Nomineret — Golden Globe Award for Best Supporting Actress – Series, Miniseries or Television Film 1995 Now and Then Tina 'Teeny' Tercell 1995 Two Much Betty Kerner 1996 Mulholland Falls Katherine Hoover 1997 Lolita Charlotte Haze 1998 Another Day in Paradise Sid 1998 Shadow of Doubt Kitt Devereux 1998 Celebrity Nicole Oliver 1999 Crazy in Alabama Lucille Vinson Nomineret — Golden Raspberry Award for Worst Actress 1999 RKO 281 Marion Davies Nomineret — Emmy Award for Outstanding Supporting Actress – Miniseries or a MovieNomineret — Golden Globe Award for Best Supporting Actress – Series, Miniseries or Television Film 2000 Cecil B. Demented Honey Whitlock Nomineret — Golden Raspberry Award for Worst Actress 2000 Forever Lulu Lulu McAfee Udgivet på DVD som Along for the Ride (2000) 2001 Tart Diane Milford 2002 Searching for Debra Winger Herself 2002 Stuart Little 2 Margalo Stemme 2003 The Night We Called It a Day Barbara Marx Nomineret — Australian Film Institute Award for Best Actress in a Supporting Role 2003 Shade Eve 2003 Tempo Sarah 2005 Heartless Miranda Wells Tv film 2007 Viva Laughlin Bunny Baxter Tv serie (2 episoder) 2010 Nip/Tuck Brandie Henry Tv serie (1 episode) 2011 Hot in Cleveland Hende selv Episode: "Sisterhood of the Traveling SPANX" 2012 American Housewife Leila Unaired Lifetime original series 2012 Dino Time Tyra (stemme) 2012 Raising Hope Tamara Tv Serie (2 episoder) 2013 Dark Tourist Betsy 2013 Call Me Crazy: A Five Film Kristin Tv film 2014 Autómata Susan Dupré 2014 Hawaii Five-0 Clara Williams Tv serie (3 episoder) 2014 Thirst Sue Kortfilm; premiere på Locarno Festival den 7. august 2014

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