Vocalmente molto simile a B. B. King, riscosse successo soprattutto col brano More And More.

Discografia parziale Album We're Gonna Make It (1965, Checker) (R&B #3 U.S. #101) Sings Big Blues (1966, Checker) Grits Ain't Groceries (1969, Stax) (R&B #41 U.S. #159) If Walls Could Talk (1970, MCA/Chess) (R&B #23 U.S. #197) Waiting for Little Milton (1973, Stax) (R&B #39) What It Is: Live at Montreux (1973, Stax) Blues 'n' Soul (1974, Stax) (R&B #45) Tin Pan Alley (1975, Stax) Friend of Mine (1976, Glades) (R&B #50) Me For You, You For Me (1977, Glades) Walkin' the Back Streets (1981, Stax) The Blues Is Alright (1982, Evidence) Age Ain't Nothin' But a Number (1983, Mobile Fidelity) (R&B #53) Playing for Keeps (1984, Malaco) (R&B #55) I Will Survive (1985, Malaco) Annie Mae's Cafe (1986, Malaco) Movin' to the Country (1987, Malaco) Back to Back (1988, Malaco) (R&B #73) Too Much Pain (1990, Malaco) (R&B #40) Reality (1991, Malaco) (R&B #57) I Need Your Love So Bad (1991, Golden Ear) Strugglin' Lady (1992, Malaco) (R&B #63) I'm a Gambler (1994, Malaco) Live at Westville Prison (1995, Delmark) Cheatin' Habit (1996, Malaco) (Blues #14) For Real (1998, Malaco) (Blues #13) Welcome to Little Milton (1999, Malaco) (Blues #10) Feel It (2001, Malaco) Guitar Man (2002, Malaco) (Blues #8) The Blues Is Alright: Live at Kalamazoo (2004, Varèse Sarabande) Think of Me (2005, Telarc) (Blues #14) Live at the North Atlantic Blues Festival: His Last Concert (2006 Camil)

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