miniatura|Fórmula esquelética da epiandrosterona.CAS: 481-29-8. miniatura|Modelo da epiandrosterona.
A epiandrosterona ou isoandrosterona, também chamada 3β-androsterona, 3β-hidroxi-5α-androstan-17-ona ou 5α-androstan-3β-ol-17-ona,ChemSpider Epiandrosterone é uma hormona esteróide com uma débil actividade androgénica. É um metabólito da testosterona e di-hidrotestosterona (DHT).
A epiandrosterona aparece de forma natural na maioria dos mamíferos, entre eles os porcos.Raeside JI, Renaud RL, Marshall DE. Identification of 5 alpha-androstane-3 beta,17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively significant secretory products of porcine Leydig cells and their presence in testicular venous blood. J Steroid Biochem Mol Biol. 42(1):113-20, 1992. PMID 1558816
A epiandrosterona produz a enzima 5α-redutase a partir da hormona adrenal desidroepiandrosterona (DHEA).PubChem EpiandrosteroneCallies F, Arlt W, Siekmann L, Hübler D, Bidlingmaier F, Allolio B. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids. 65(2):98-102, 2000. PMID 10639021Labrie F, Cusan L, Gomez JL, Martel C, Bérubé R, Bélanger P, Chaussade V, Deloche C, Leclaire J. Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol. 2008 May;110(1-2):1-9. PMID 18359622. DOI 10.1016/j.jsbmb.2008.02.003Daniël Henri van de Kerkhof. Steroid profiling in doping analysis. [S.l.] : [s.n.], 2001 - Tekst. - Proefschrift Universiteit Utrecht Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril. Mar;81(3):595-604, 2004. PMID 15037408. DOI 10.1016/j.fertnstert.2003.07.035
Ver também 3β-Androstanediol Androstenol Androstenona Estratetraenol
Bibliografia Simons RG, Grinwich DL. Immunoreactive detection of four mammalian steroids in plants. Can J Bot 67: 288-296, 1989 Janeczko A, Skoczowski A. Mammalian sex hormones in plants. Folia Histochem Cytobiol. 2005;43(2):71-9.Labrie F, Bélanger A, Labrie C, Candas B, Cusan L, Gomez 4. JL. Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women. J Steroid Biochem Mol Biol. 107(1-2):57-69, 2007 Uralets VP, Gillette PA. Over-the-counter delta5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3beta, 17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione: excretion studies in men. J Anal Toxicol. 24(3):188-93, 2000
Categoria:Hormônios Categoria:Esteroides