SNC-80

-{ SNC-80}- je opioidni analgetik koji se koristi u načnim istraživanjima.C-{alderon SN, Coop A. SNC 80 and related delta opioid agonists. .}- On je pronađen 1994.Calderon SN, Rothman RB, Porreca F, Flippen-Anderson JL, McNutt RW, Xu H, Smith LE, Bilsky EJ, Davis P, Rice KC. Probes for narcotic receptor mediated phenomena. 19. Synthesis of (+)-4-[(alpha R)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3- methoxybenzyl]-N,N-diethylbenzamide (SNC 80): a highly selective, nonpeptide delta opioid receptor agonist. . -{SNC-80}- je bio prvi ne-peptidni lek koji je visoko selektivni agonist δ-opioidnog receptora.-{Bilsky EJ, Calderon SN, Wang T, Bernstein RN, Davis P, Hruby VJ, McNutt RW, Rothman RB, Rice KC, Porreca F. SNC 80, a selective, nonpeptidic and systemically active opioid delta agonist. .}--{Knapp RJ, Santoro G, De Leon IA, Lee KB, Edsall SA, Waite S, Malatynska E, Varga E, Calderon SN, Rice KC, Rothman RB, Porreca F, Roeske WR, Yamamura HI. Structure-activity relationships for SNC80 and related compounds at cloned human delta and mu opioid receptors. .}-

Za njega je pokazano da proizvodi analgetske,-{Gallantine EL, Meert TF. A comparison of the antinociceptive and adverse effects of the mu-opioid agonist morphine and the delta-opioid agonist SNC80. .}- antidepresantske-{Jutkiewicz EM, Rice KC, Traynor JR, Woods JH. Separation of the convulsions and antidepressant-like effects produced by the delta-opioid agonist SNC80 in rats. .}- i anksiolitske| efekte u životinjskim studijama,-{Perrine SA, Hoshaw BA, Unterwald EM. Delta opioid receptor ligands modulate anxiety-like behaviors in the rat. .}--{Saitoh A, Kimura Y, Suzuki T, Kawai K, Nagase H, Kamei J. Potential anxiolytic and antidepressant-like activities of SNC80, a selective delta-opioid agonist, in behavioral models in rodents. .}- ali je njegova upotrebljivost ograničena proizvođenjem konvulzija na visokim dozama,-{Danielsson I, Gasior M, Stevenson GW, Folk JE, Rice KC, Negus SS. Electroencephalographic and convulsant effects of the delta opioid agonist SNC80 in rhesus monkeys. .}- tako da se -{SNC-80}- nema medicinsku primenu, mada je koristan lek za naučna istraživanja.

Reference

Spoljašnje veze

Категорија:Опиоиди Категорија:Делта-опиоидни агонисти Категорија:Бензамиди Категорија:Пиперазини Категорија:Фенолни етри Категорија:Алкени