La tirosina-tRNA ligasi è un enzima, appartenente alla classe delle ligasi, che catalizza la seguente reazione:
ATP + L-tirosina + tRNATyr = AMP + difosfato + L-tirosil-tRNATyr
Bibliografia Allen, E.H., Glassman, E. e Schweet, R.S. Incorporation of amino acids into ribonucleic acid. I. The role of activating enzymes. J. Biol. Chem. 235 (1960) 1061–1067. Cowles, J.R. e Key, J.L. Demonstration of two tyrosyl-tRNA synthetases of pea roots. Biochim. Biophys. Acta 281 (1972) 33–44. Holley, R.W., Brunngraber, E.F., Saad, F. e Williams, H.H. Partial purification of the threonine- and tyrosine-activating enzymes from rat liver, and the effect of potassium ions on the activity of the tyrosine enzyme. J. Biol. Chem. 236 (1961) 197–199. Schweet, R.S. e Allen, E.H. Purification and properties of tyrosine-activating enzyme of hog pancreas. J. Biol. Chem. 233 (1958) 1104–1108. Brick, P., Bhat, T.N. e Blow, D.M. Structure of tyrosyl-tRNA synthetase refined at 2.3 Å resolution. Interaction of the enzyme with the tyrosyl adenylate intermediate. J. Mol. Biol. 208 (1989) 83–98.
Categoria:EC 6.1.1